UNC 0646 ( —— )

产品货号. M22061 CAS No. 1320288-17-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

UNC 0646
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP).
产品描述

UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).
同义词

——
通路

Others
靶点

Other Targets
受体

G9a; GLP
研究领域

——
适应症

——

CAS Number

1320288-17-2
分子量

621.9
分子式

C36H59N7O2
纯度

>98% (HPLC)
溶解度

DMSO:30 mg/mL (48.24 mM; Need ultrasonic)
SMILES

COC1=C(OCCCN2CCCCC2)C=C2N=C(N=C(NC3CCN(CC3)C3CCCCC3)C2=C1)N1CCCN(CC1)C(C)C
化学全称

——

1.Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.

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